منابع مشابه
Melatonin modulates drug-induced acute porphyria
This work investigated the modulation by melatonin (Mel) of the effects of the porphyrinogenic drugs 2-allyl-2-isopropylacetamide (AIA) and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-collidine (DDC) on oxidative environment, glucose biosynthesis and heme pathway parameters. Administration of Mel before rat intoxication with AIA/DDC showed a clear beneficial effect in all cases. Mel induced decrease...
متن کاملAcute intermittent porphyria--diagnostic and treatment traps.
Acute intermittent porphyria (AIP) is a rare metabolic disease defined by mutations coding the deaminaze enzyme of porphobilinogen (PBGD). Porphyrias are somewhat misdiagnosed as a consequence of light symptoms in patients. Acute forms of porphyria can be life-threatening, so a correct diagnosis and an accurate treatment are highly important. The authors presented the case of a 38-years-old pat...
متن کاملAcute intermittent porphyria: pathophysiology and treatment.
Acute intermittent porphyria is caused by an inherent error of porphyrin metabolism characterized by a deficiency of porphobilinogen deaminase and increased activity of delta-aminolevulinic acid synthase, key enzymes necessary for the biosynthesis of heme. During an attack patients may have abdominal pain, vomiting, muscle weakness, constipation and neuropsychiatric symptoms. In the majority of...
متن کاملAcute Porphyria
PORPHYRIA is a rare disorder of metabolism, in which there is increased production and excretion of uroporphyrin, coproporphyrin, and porphobilinogen.' Despite recent reviews (Goldman and Kaplan (1951), Watson (1951), and Janoff, Poutas, and Young (1953) ), the disease is unfamiliar, but recently there have been an increasing number of case reports. Acute porphyria may present such varied sympt...
متن کاملCimetidine in the treatment of acute intermittent porphyria.
Treatment options for AIP remain limited. Although no single therapy has been proven superior in clinical trials, intravenous hemin appears to be more effective than increased carbohydrate intake, and remains the treatment of choice. At usual dosages the average wholesale price of hemin is $120-475 per day (for a patient weighing 70 kg), compared with $2.50 per day for cimetidine. Cimetidine ma...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1997
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.1997.t01-1-00609.x